Assay Detail
Binding
CHEMBL748771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-5-7 dichlorokynurenic acid ([3H]- DCKA) from N-methyl-D-aspartate glutamate receptor glycine site of rat brain membrane homogenate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.35 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139982 | — | — | 1 | 8.15 |
| CHEMBL138208 | — | — | 1 | 7.86 |
| CHEMBL31741 | — | — | 1 | 7.85 |
| CHEMBL337346 | — | — | 1 | 7.62 |
| CHEMBL136791 | — | — | 1 | 7.62 |
| CHEMBL337851 | — | — | 1 | 7.57 |
| CHEMBL138159 | — | — | 1 | 7.38 |
| CHEMBL139009 | — | — | 1 | 7.32 |
| CHEMBL344145 | — | — | 1 | 7.19 |
| CHEMBL136501 | — | — | 1 | 6.67 |
| CHEMBL137509 | — | — | 1 | 6.56 |
| CHEMBL276907 | — | — | 1 | 6.37 |
| CHEMBL138491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139982 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL138208 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL31741 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL337346 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL136791 | — | Ki | = | 24.2 | nM | 7.62 |
| CHEMBL337851 | — | Ki | = | 26.8 | nM | 7.57 |
| CHEMBL138159 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL139009 | — | Ki | = | 47.6 | nM | 7.32 |
| CHEMBL344145 | — | Ki | = | 64.3 | nM | 7.19 |
| CHEMBL136501 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL137509 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL276907 | — | Ki | = | 427.0 | nM | 6.37 |
| CHEMBL138491 | — | Ki | > | 1000.0 | nM | - |