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Assay Detail

CHEMBL748788

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested in vitro for the affinity against NMDA receptor in a cortical wedge assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Glutamate [NMDA] receptor (CHEMBL2094124)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Tetrazole amino acids as competitive NMDA antagonists
Ornstein PL, Arnold M, Evrard D, Leander J, Lodge D, Schoepp DD
Bioorg Med Chem Lett (1993) 3 : 43 -48
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.28 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL22304 1 6.22
CHEMBL39664 SELFOTEL 2.0 1 5.80
CHEMBL84612 1 5.43
CHEMBL173031 1 5.38
CHEMBL145406 1 5.33
CHEMBL145362 1 5.09
CHEMBL302783 1 4.96
CHEMBL145074 1 4.79
CHEMBL146168 1 4.50
CHEMBL357426 1 -
CHEMBL544391 1 -
CHEMBL357463 1 -
CHEMBL145728 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL22304 IC50 = 600.0 nM 6.22
CHEMBL39664 SELFOTEL IC50 = 1600.0 nM 5.80
CHEMBL84612 IC50 = 3700.0 nM 5.43
CHEMBL173031 IC50 = 4200.0 nM 5.38
CHEMBL145406 IC50 = 4700.0 nM 5.33
CHEMBL145362 IC50 = 8200.0 nM 5.09
CHEMBL302783 IC50 = 11100.0 nM 4.96
CHEMBL145074 IC50 = 16300.0 nM 4.79
CHEMBL146168 IC50 = 31600.0 nM 4.50
CHEMBL357426 IC50 > 100000.0 nM -
CHEMBL544391 IC50 > 100000.0 nM -
CHEMBL357463 IC50 > 100000.0 nM -
CHEMBL145728 IC50 > 100000.0 nM -