Assay Detail
Functional
CHEMBL748865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Epibatidine structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.86 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 10.59 |
| CHEMBL58935 | — | — | 1 | 9.62 |
| CHEMBL58881 | — | — | 1 | 9.62 |
| CHEMBL56064 | — | — | 1 | 9.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.026 | nM | 10.59 |
| CHEMBL58935 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL58881 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL56064 | — | Ki | = | 0.26 | nM | 9.59 |