Assay Detail
Binding
CHEMBL748875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of influenza A viral enzyme neuraminidase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Fragment-based drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.57 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.89 |
| CHEMBL320978 | — | — | 1 | 7.07 |
| CHEMBL325456 | — | — | 1 | 5.79 |
| CHEMBL115466 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL320978 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL325456 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL115466 | — | IC50 | = | 31000.0 | nM | 4.51 |