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Assay Detail

CHEMBL748877

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Binding
Inhibition of neuraminidase of influenza B
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza B virus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Neuraminidase (CHEMBL3377)
Type SINGLE PROTEIN
Organism Influenza B virus (strain B/Lee/1940)

Publication

A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.
Lew W, Wu H, Mendel DB, Escarpe PA, Chen X, Laver WG, Graves BJ, Kim CU.
Bioorg Med Chem Lett (1998) 8 : 3321 -3324
PubMed 9873727 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.75 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL674 OSELTAMIVIR CARBOXYLATE -1.0 1 8.40
CHEMBL112356 1 7.22
CHEMBL420120 1 7.22
CHEMBL440151 1 7.19
CHEMBL320978 1 7.00
CHEMBL113102 1 6.76
CHEMBL111857 1 6.62
CHEMBL112581 1 6.30
CHEMBL113191 1 6.25
CHEMBL320496 1 5.77
CHEMBL331151 1 5.50
CHEMBL320788 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL674 OSELTAMIVIR CARBOXYLATE IC50 = 4.0 nM 8.40
CHEMBL112356 IC50 = 60.0 nM 7.22
CHEMBL420120 IC50 = 60.0 nM 7.22
CHEMBL440151 IC50 = 65.0 nM 7.19
CHEMBL320978 IC50 = 100.0 nM 7.00
CHEMBL113102 IC50 = 175.0 nM 6.76
CHEMBL111857 IC50 = 240.0 nM 6.62
CHEMBL112581 IC50 = 500.0 nM 6.30
CHEMBL113191 IC50 = 565.0 nM 6.25
CHEMBL320496 IC50 = 1700.0 nM 5.77
CHEMBL331151 IC50 = 3200.0 nM 5.50
CHEMBL320788 IC50 > 1000.0 nM -