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Assay Detail

CHEMBL749041

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Binding
Inhibition of N-arachidonoylethanolamine transporter (AEA) activity in human lymphoma U937 cell using [3H]AEA as substrate in the 0-1000 nM conc.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type U-937
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.
van der Stelt M, van Kuik JA, Bari M, van Zadelhoff G, Leeflang BR, Veldink GA, Finazzi-Agrò A, Vliegenthart JF, Maccarrone M.
J Med Chem (2002) 45 : 3709 -3720
PubMed 12166944 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 5.18 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL122972 2-ARACHIDONOYLGLYCEROL 1 5.52
CHEMBL332236 1 5.16
CHEMBL122195 1 5.05
CHEMBL262560 1 5.00
CHEMBL124426 1 -
CHEMBL440338 1 -
CHEMBL122267 1 -
CHEMBL122729 1 -
CHEMBL333114 1 -
CHEMBL121778 1 -
CHEMBL121779 1 -
CHEMBL15848 ANANDAMIDE 1 -
CHEMBL121804 1 -
CHEMBL126042 1 -
CHEMBL331254 1 -
CHEMBL331170 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL122972 2-ARACHIDONOYLGLYCEROL Ki = 3000.0 nM 5.52
CHEMBL332236 Ki = 7000.0 nM 5.16
CHEMBL122195 Ki = 9000.0 nM 5.05
CHEMBL262560 Ki = 10000.0 nM 5.00
CHEMBL124426 Ki > 10000.0 nM -
CHEMBL440338 Ki > 10000.0 nM -
CHEMBL122267 Ki > 10000.0 nM -
CHEMBL122729 Ki > 10000.0 nM -
CHEMBL333114 Ki > 10000.0 nM -
CHEMBL121778 Ki > 10000.0 nM -
CHEMBL121779 Ki > 10000.0 nM -
CHEMBL15848 ANANDAMIDE Ki > 10000.0 nM -
CHEMBL121804 Ki > 10000.0 nM -
CHEMBL126042 Ki > 10000.0 nM -
CHEMBL331254 Ki > 10000.0 nM -
CHEMBL331170 Ki > 10000.0 nM -