Assay Detail
Binding
CHEMBL749246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of complex I activity was determined by NADH oxidase assay using bovine heart submitochondrial particles.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mitochondrial complex I; NADH oxidoreductase (CHEMBL614865) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Synthesis and inhibitory activity of ubiquinone-acetogenin hybrid inhibitor with bovine mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.78 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62800 | ISODESAACETYLUVARICIN | — | 1 | 9.05 |
| CHEMBL1159657 | BULLATACIN | — | 1 | 9.05 |
| CHEMBL80522 | — | — | 1 | 8.92 |
| CHEMBL75627 | — | — | 1 | 6.55 |
| CHEMBL80354 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62800 | ISODESAACETYLUVARICIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1159657 | BULLATACIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL80522 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL75627 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL80354 | — | IC50 | = | 4500.0 | nM | 5.35 |