Assay Detail
Binding
CHEMBL749247
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Inhibitory activity against NADH oxidase in beef heart mitochondrial complex I.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mitochondrial complex I; NADH oxidoreductase (CHEMBL614865) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Inhibitory effects on mitochondrial complex I of semisynthetic mono-tetrahydrofuran acetogenin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.53 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133177 | — | — | 1 | 9.15 |
| CHEMBL134189 | — | — | 1 | 9.10 |
| CHEMBL131461 | — | — | 1 | 8.72 |
| CHEMBL439797 | — | — | 1 | 8.64 |
| CHEMBL133015 | — | — | 1 | 8.57 |
| CHEMBL131124 | — | — | 1 | 8.48 |
| CHEMBL132607 | — | — | 1 | 8.44 |
| CHEMBL429023 | ROTENONE | — | 1 | 8.29 |
| CHEMBL131462 | — | — | 1 | 8.24 |
| CHEMBL131506 | — | — | 1 | 7.66 |
| CHEMBL133297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133177 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL134189 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL131461 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL439797 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL133015 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL131124 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL132607 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL429023 | ROTENONE | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL131462 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL131506 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL133297 | — | IC50 | > | 150.0 | nM | - |