Assay Detail
Binding
CHEMBL749249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for the inhibition of NADH oxidase in submitochondrial particles from beef heart
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mitochondrial complex I; NADH oxidoreductase (CHEMBL614865) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Rollimembrin, a novel acetogenin inhibitor of mammalian mitochondrial complex I
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.32 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268185 | — | — | 1 | 9.48 |
| CHEMBL13710 | — | — | 1 | 9.24 |
| CHEMBL13700 | — | — | 1 | 9.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268185 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL13710 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL13700 | — | IC50 | = | 0.58 | nM | 9.24 |