Assay Detail
Functional
CHEMBL749250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NADH oxidase activity in sub-mitochondrial particles from bovine heart
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mitochondrial complex I; NADH oxidoreductase (CHEMBL614865) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.23 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159443 | — | — | 1 | 9.74 |
| CHEMBL160640 | LAHERRADURIN | — | 1 | 9.74 |
| CHEMBL609932 | — | — | 1 | 9.68 |
| CHEMBL349693 | — | — | 1 | 9.68 |
| CHEMBL351789 | — | — | 1 | 9.64 |
| CHEMBL349802 | — | — | 1 | 9.48 |
| CHEMBL161493 | — | — | 1 | 9.37 |
| CHEMBL161030 | — | — | 1 | 9.27 |
| CHEMBL142918 | rolliniastatin-1 | — | 1 | 9.22 |
| CHEMBL161529 | — | — | 1 | 9.08 |
| CHEMBL159586 | — | — | 1 | 8.91 |
| CHEMBL345841 | — | — | 1 | 8.73 |
| CHEMBL162504 | — | — | 1 | 8.61 |
| CHEMBL608197 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159443 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL160640 | LAHERRADURIN | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL609932 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL349693 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL351789 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL349802 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL161493 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL161030 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL142918 | rolliniastatin-1 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL161529 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL159586 | — | IC50 | = | 1.22 | nM | 8.91 |
| CHEMBL345841 | — | IC50 | = | 1.84 | nM | 8.73 |
| CHEMBL162504 | — | IC50 | = | 2.48 | nM | 8.61 |
| CHEMBL608197 | — | IC50 | = | 8.47 | nM | 8.07 |