Assay Detail
Binding
CHEMBL749251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration needed to halve the control NADH oxidase activity in bovine heart submitochondrial particles (SMP)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mitochondrial complex I; NADH oxidoreductase (CHEMBL614865) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Essential structural features of acetogenins: role of hydroxy groups adjacent to the bis-THF rings.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.32 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62800 | ISODESAACETYLUVARICIN | — | 1 | 9.12 |
| CHEMBL164819 | — | — | 1 | 8.57 |
| CHEMBL166222 | — | — | 1 | 8.51 |
| CHEMBL352106 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62800 | ISODESAACETYLUVARICIN | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL164819 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL166222 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL352106 | — | IC50 | = | 85.0 | nM | 7.07 |