Assay Detail
Binding
CHEMBL749252
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Inhibition of NADH oxidase activity.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mitochondrial complex I; NADH oxidoreductase (CHEMBL614865) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 9.01 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145554 | — | — | 1 | 9.60 |
| CHEMBL145449 | BULLANIN | — | 1 | 9.49 |
| CHEMBL145222 | — | — | 1 | 9.48 |
| CHEMBL358586 | — | — | 1 | 9.47 |
| CHEMBL142276 | — | — | 1 | 9.47 |
| CHEMBL141607 | — | — | 1 | 9.47 |
| CHEMBL66691 | MOTRILIN | — | 1 | 9.39 |
| CHEMBL144981 | — | — | 1 | 9.38 |
| CHEMBL1159657 | BULLATACIN | — | 1 | 9.29 |
| CHEMBL41177 | SQUAMOCIN | — | 1 | 9.23 |
| CHEMBL142918 | rolliniastatin-1 | — | 1 | 9.22 |
| CHEMBL357666 | — | — | 1 | 9.19 |
| CHEMBL359434 | — | — | 1 | 9.13 |
| CHEMBL145455 | — | — | 1 | 9.02 |
| CHEMBL145485 | — | — | 1 | 8.84 |
| CHEMBL145624 | GUANACONE | — | 1 | 8.82 |
| CHEMBL145484 | — | — | 1 | 8.78 |
| CHEMBL145555 | — | — | 1 | 8.78 |
| CHEMBL357600 | — | — | 1 | 8.68 |
| CHEMBL145064 | — | — | 1 | 8.54 |
| CHEMBL145563 | — | — | 1 | 8.30 |
| CHEMBL145073 | — | — | 1 | 7.85 |
| CHEMBL344296 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145554 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL145449 | BULLANIN | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL145222 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL358586 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL142276 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL141607 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL66691 | MOTRILIN | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL144981 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL1159657 | BULLATACIN | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL41177 | SQUAMOCIN | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL142918 | rolliniastatin-1 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL357666 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL359434 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL145455 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL145485 | — | IC50 | = | 1.46 | nM | 8.84 |
| CHEMBL145624 | GUANACONE | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL145484 | — | IC50 | = | 1.65 | nM | 8.78 |
| CHEMBL145555 | — | IC50 | = | 1.68 | nM | 8.78 |
| CHEMBL357600 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL145064 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL145563 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL145073 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL344296 | — | IC50 | = | 18.0 | nM | 7.75 |