Assay Detail
Binding
CHEMBL749255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against bovine heart mitochondrial NADH ubiquinone oxidoreductase (complex I)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (CHEMBL2503) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.78 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62800 | ISODESAACETYLUVARICIN | — | 1 | 9.05 |
| CHEMBL302867 | — | — | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62800 | ISODESAACETYLUVARICIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL302867 | — | IC50 | = | 3.1 | nM | 8.51 |