Assay Detail
Binding
CHEMBL749256
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Inhibitory activity against NADH/DH oxidoreductase in beef heart mitochondrial complex I.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitory effects on mitochondrial complex I of semisynthetic mono-tetrahydrofuran acetogenin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.87 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133177 | — | — | 1 | 8.96 |
| CHEMBL134189 | — | — | 1 | 8.43 |
| CHEMBL131461 | — | — | 1 | 8.06 |
| CHEMBL133015 | — | — | 1 | 7.99 |
| CHEMBL131124 | — | — | 1 | 7.84 |
| CHEMBL132607 | — | — | 1 | 7.70 |
| CHEMBL439797 | — | — | 1 | 7.58 |
| CHEMBL429023 | ROTENONE | — | 1 | 7.54 |
| CHEMBL131462 | — | — | 1 | 7.29 |
| CHEMBL131506 | — | — | 1 | 7.26 |
| CHEMBL133297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133177 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL134189 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL131461 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL133015 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL131124 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL132607 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL439797 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL429023 | ROTENONE | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL131462 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL131506 | — | IC50 | = | 55.2 | nM | 7.26 |
| CHEMBL133297 | — | IC50 | > | 1200.0 | nM | - |