Assay Detail
Binding
CHEMBL749258
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Inhibition of NADH:ubiquinone oxidoreductase from house fly (Musca domestica) flight muscles
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Musca domestica |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The design and synthesis of novel inhibitors of NADH:ubiquinone oxidoreductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.40 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149071 | — | — | 1 | 8.22 |
| CHEMBL356903 | — | — | 1 | 8.10 |
| CHEMBL148678 | — | — | 1 | 8.00 |
| CHEMBL406144 | — | — | 1 | 7.70 |
| CHEMBL150165 | — | — | 1 | 6.80 |
| CHEMBL149291 | — | — | 1 | 6.70 |
| CHEMBL146148 | — | — | 1 | 6.30 |
| CHEMBL149072 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149071 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL356903 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL148678 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL406144 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL150165 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL149291 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL146148 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL149072 | — | IC50 | > | 200.0 | nM | - |