Assay Detail
Binding
CHEMBL749307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]-iodo-MLA binding to Nicotinic acetylcholine receptor alpha-7 from rat brain membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Epibatidine structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.02 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417027 | — | — | 1 | 8.95 |
| CHEMBL54686 | — | — | 1 | 8.46 |
| CHEMBL55716 | AZIDOEPIBATIDINE | — | 1 | 8.01 |
| CHEMBL55661 | — | — | 1 | 7.86 |
| CHEMBL56340 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417027 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL54686 | — | Ki | = | 3.43 | nM | 8.46 |
| CHEMBL55716 | AZIDOEPIBATIDINE | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL55661 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL56340 | — | Ki | = | 152.0 | nM | 6.82 |