Assay Detail
Binding
CHEMBL749346
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Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells
15
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.66 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330789 | — | — | 3 | 7.64 |
| CHEMBL125069 | — | — | 1 | 7.58 |
| CHEMBL339774 | — | — | 1 | 7.23 |
| CHEMBL122091 | — | — | 1 | 6.96 |
| CHEMBL420156 | — | — | 3 | 6.89 |
| CHEMBL124899 | — | — | 1 | 6.43 |
| CHEMBL121877 | — | — | 1 | 6.29 |
| CHEMBL331299 | — | — | 1 | 6.12 |
| CHEMBL122440 | — | — | 1 | 6.02 |
| CHEMBL125092 | — | — | 1 | 5.77 |
| CHEMBL121932 | BENZOCLIDINE | 2.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330789 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL125069 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL339774 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL330789 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL122091 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL420156 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL420156 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL420156 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL330789 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL124899 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL121877 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL331299 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL122440 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL125092 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL121932 | BENZOCLIDINE | IC50 | = | 2600.0 | nM | 5.58 |