Assay Detail
Binding
CHEMBL749392
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Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Piperidine-ether based hNK1 antagonists 1: Determination of the relative and absolute stereochemical requirements
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.02 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 9.15 |
| CHEMBL27006 | — | — | 1 | 9.00 |
| CHEMBL85047 | — | — | 2 | 8.85 |
| CHEMBL84588 | — | — | 1 | 8.15 |
| CHEMBL315532 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL27006 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL85047 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL84588 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL315532 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL85047 | — | IC50 | = | 350.0 | nM | 6.46 |