Assay Detail
Binding
CHEMBL749395
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Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,3-Substituted 2-azanorbornanes as polar -turn mimetics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.43 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334721 | — | — | 1 | 6.10 |
| CHEMBL32940 | — | — | 1 | 5.43 |
| CHEMBL118194 | — | — | 1 | 5.17 |
| CHEMBL118328 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334721 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL32940 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL118194 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL118328 | — | IC50 | = | 9300.0 | nM | 5.03 |