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Assay Detail

CHEMBL749469

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Functional
Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Publication

Batrachotoxin binding site antagonists
Schow S, Rossignol D, Lund A, Schnee M
Bioorg Med Chem Lett (1997) 7 : 181 -186
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.50 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL698 TETRACAINE 4.0 1 6.40
CHEMBL52359 1 6.30
CHEMBL55733 1 5.40
CHEMBL296366 1 5.30
CHEMBL298513 1 4.10
CHEMBL52258 1 -
CHEMBL55922 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL698 TETRACAINE IC50 = 400.0 nM 6.40
CHEMBL52359 IC50 = 500.0 nM 6.30
CHEMBL55733 IC50 = 4000.0 nM 5.40
CHEMBL296366 IC50 = 5000.0 nM 5.30
CHEMBL298513 IC50 = 80000.0 nM 4.10
CHEMBL52258 IC50 = 200000.0 nM -
CHEMBL55922 IC50 = 1000000.0 nM -