Assay Detail
Binding
CHEMBL749476
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Tested for the binding affinity against neurokinin NK1 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Studies on the active conformation of the NK1 antagonist CGP 49823. Part 21. Fluoro-olefin analogs of tertiary amide rotamers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.85 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290364 | — | — | 1 | 7.92 |
| CHEMBL116535 | — | — | 1 | 7.82 |
| CHEMBL297883 | — | — | 1 | 6.89 |
| CHEMBL262301 | — | — | 1 | 6.57 |
| CHEMBL120126 | — | — | 1 | 6.42 |
| CHEMBL326613 | — | — | 1 | 6.21 |
| CHEMBL332759 | — | — | 1 | 6.15 |
| CHEMBL436364 | — | — | 1 | - |
| CHEMBL331613 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290364 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL116535 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL297883 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL262301 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL120126 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL326613 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL332759 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL436364 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL331613 | — | IC50 | > | 10000.0 | nM | - |