Assay Detail
Binding
CHEMBL749477
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Tested for the inhibitory potency against Neurokinin 1 NK1 receptor
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Studies on the active conformation of NK1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.77 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290364 | — | — | 1 | 7.92 |
| CHEMBL332111 | — | — | 1 | 7.52 |
| CHEMBL419232 | — | — | 2 | 7.36 |
| CHEMBL119025 | — | — | 1 | 6.00 |
| CHEMBL333726 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290364 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL332111 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL419232 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL419232 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL119025 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL333726 | — | IC50 | = | 2300.0 | nM | 5.64 |