Assay Detail
Binding
CHEMBL749504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against influenza A neuraminidase from influenza A/PR/8/34 (H1N1).
37
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (strain: A/PR/8/34) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.45 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81286 | — | — | 1 | 9.52 |
| CHEMBL2114178 | — | — | 2 | 9.30 |
| CHEMBL81717 | — | — | 1 | 9.30 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 9.00 |
| CHEMBL310004 | — | — | 1 | 9.00 |
| CHEMBL315261 | — | — | 1 | 9.00 |
| CHEMBL311288 | — | — | 1 | 9.00 |
| CHEMBL311205 | — | — | 1 | 8.70 |
| CHEMBL81790 | — | — | 1 | 8.52 |
| CHEMBL309834 | — | — | 1 | 8.52 |
| CHEMBL81777 | — | — | 1 | 8.52 |
| CHEMBL3220444 | — | — | 1 | 8.05 |
| CHEMBL2114179 | — | — | 1 | 8.00 |
| CHEMBL79499 | — | — | 1 | 7.92 |
| CHEMBL430814 | — | — | 1 | 7.80 |
| CHEMBL51955 | — | — | 1 | 7.22 |
| CHEMBL81083 | — | — | 1 | 7.05 |
| CHEMBL312637 | — | — | 1 | 7.00 |
| CHEMBL82771 | — | — | 1 | 6.82 |
| CHEMBL54758 | — | — | 1 | 6.75 |
| CHEMBL81637 | — | — | 1 | 6.75 |
| CHEMBL83932 | — | — | 1 | 6.70 |
| CHEMBL79524 | — | — | 1 | 6.70 |
| CHEMBL418913 | — | — | 1 | 6.68 |
| CHEMBL81953 | — | — | 1 | 6.57 |
| CHEMBL79908 | — | — | 1 | 6.52 |
| CHEMBL298659 | — | — | 1 | 6.28 |
| CHEMBL311274 | — | — | 1 | 6.22 |
| CHEMBL310217 | — | — | 1 | 6.21 |
| CHEMBL311273 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81286 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2114178 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL81717 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2114178 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL310004 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL315261 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL311288 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL311205 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL81790 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL309834 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL81777 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3220444 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2114179 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL79499 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL430814 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL51955 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL81083 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL312637 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL82771 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL54758 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL81637 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL83932 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL79524 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL418913 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL81953 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL79908 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL298659 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL311274 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL310217 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL311273 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL309419 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL53336 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL312047 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL81159 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL420038 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL309616 | — | IC50 | > | 1000.0 | nM | - |