Assay Detail
Binding
CHEMBL749508
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Tested for the affinity to the glycine site -NMDA receptor using [3H]Gly as radioligand.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-sulfonyl derivatives of 6,7-dichloro 3,4-dihydro-3-oxo-quinoxalinecarboxylate as glycine-site NMDA and AMPA antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.59 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 7.17 |
| CHEMBL126035 | — | — | 1 | 6.92 |
| CHEMBL167548 | — | — | 1 | 6.44 |
| CHEMBL130213 | 6,7-DICHLORO-3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID | — | 1 | 6.34 |
| CHEMBL155265 | DNQX | — | 1 | 6.08 |
| CHEMBL222519 | NBQX | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL126035 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL167548 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL130213 | 6,7-DICHLORO-3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL155265 | DNQX | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL222519 | NBQX | IC50 | > | 100000.0 | nM | - |