Assay Detail
Binding
CHEMBL749551
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Affinity for alpha-7 neuronal nicotinic acetylcholine receptor subtype determined by inhibition of [3H]-MLA binding to rat brain membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.05 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282473 | — | — | 1 | 7.39 |
| CHEMBL417278 | — | — | 1 | 6.23 |
| CHEMBL21553 | — | — | 1 | 6.22 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.11 |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | 5.87 |
| CHEMBL510275 | METHYLLYCACONITINE | — | 1 | 5.81 |
| CHEMBL22285 | — | — | 1 | 4.70 |
| CHEMBL21816 | — | — | 1 | - |
| CHEMBL277416 | — | — | 1 | - |
| CHEMBL281410 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282473 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL417278 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL21553 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL3 | NICOTINE | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL6200 | NORNICOTINE | Ki | = | 1340.0 | nM | 5.87 |
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL22285 | — | Ki | = | 20200.0 | nM | 4.70 |
| CHEMBL21816 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL277416 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL281410 | — | Ki | > | 100000.0 | nM | - |