Assay Detail
Binding
CHEMBL749556
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Binding affinity at rat brain Nicotinic acetylcholine receptor alpha7
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.01 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111008 | — | — | 1 | 7.17 |
| CHEMBL274538 | — | — | 1 | 7.05 |
| CHEMBL6623 | EPIBATIDINE | — | 1 | 7.00 |
| CHEMBL25619 | — | — | 1 | 5.94 |
| CHEMBL10886 | — | — | 1 | 5.77 |
| CHEMBL63102 | — | — | 1 | 5.56 |
| CHEMBL10863 | — | — | 1 | 5.24 |
| CHEMBL327104 | — | — | 1 | 4.32 |
| CHEMBL323045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111008 | — | Ki | = | 68.4 | nM | 7.17 |
| CHEMBL274538 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL6623 | EPIBATIDINE | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL25619 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL10886 | — | Ki | = | 1706.0 | nM | 5.77 |
| CHEMBL63102 | — | Ki | = | 2760.0 | nM | 5.56 |
| CHEMBL10863 | — | Ki | = | 5773.0 | nM | 5.24 |
| CHEMBL327104 | — | Ki | = | 47500.0 | nM | 4.32 |
| CHEMBL323045 | — | Ki | > | 50000.0 | nM | - |