Assay Detail
Binding
CHEMBL749561
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Binding affinity to subtype Nicotinic acetylcholine receptor alpha7 using [3H]-MLA as radioligand in rat brain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.71 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274538 | — | — | 1 | 9.02 |
| CHEMBL10886 | — | — | 1 | 7.97 |
| CHEMBL275466 | — | — | 1 | 7.92 |
| CHEMBL25619 | — | — | 1 | 7.05 |
| CHEMBL10863 | — | — | 1 | 6.60 |
| CHEMBL10585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274538 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL10886 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL275466 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL25619 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL10863 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL10585 | — | Ki | > | 10.0 | nM | - |