Assay Detail
Binding
CHEMBL749562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Nicotinic acetylcholine receptor alpha-7 using [3H]-MLA as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.86 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444572 | — | — | 1 | 7.05 |
| CHEMBL93983 | — | — | 1 | 6.03 |
| CHEMBL329084 | — | — | 1 | 5.88 |
| CHEMBL1086655 | — | — | 1 | 5.56 |
| CHEMBL96828 | — | — | 1 | 4.80 |
| CHEMBL419700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444572 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL93983 | — | Ki | = | 927.0 | nM | 6.03 |
| CHEMBL329084 | — | Ki | = | 1306.0 | nM | 5.88 |
| CHEMBL1086655 | — | Ki | = | 2760.0 | nM | 5.56 |
| CHEMBL96828 | — | Ki | = | 15980.0 | nM | 4.80 |
| CHEMBL419700 | — | Ki | > | 50000.0 | nM | - |