Assay Detail
Binding
CHEMBL749669
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Binding affinity against dextromethorpin binding site associated with N-methyl-D-aspartate glutamate receptor from guinea pig mitochondrial pellet P2 determined using [3H]1 as radioligand.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.32 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435790 | — | — | 1 | 7.05 |
| CHEMBL133532 | — | — | 1 | 6.82 |
| CHEMBL133531 | — | — | 1 | 6.80 |
| CHEMBL22207 | RACEMETHORPHAN | 2.0 | 1 | 6.62 |
| CHEMBL336430 | — | — | 1 | 6.43 |
| CHEMBL133401 | — | — | 1 | 6.36 |
| CHEMBL337277 | — | — | 1 | 6.17 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 5.96 |
| CHEMBL334822 | — | — | 1 | 5.77 |
| CHEMBL130193 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435790 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL133532 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL133531 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL22207 | RACEMETHORPHAN | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL336430 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL133401 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL337277 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL334822 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL130193 | — | IC50 | = | 6400.0 | nM | 5.19 |