Assay Detail
Binding
CHEMBL749999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at delta opioid receptor in guinea pig brain by [3H]c[D-Pen2, p-Cl-Phe4, D-Pen5]-enkephalin displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.43 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112652 | — | — | 1 | 7.86 |
| CHEMBL2370618 | — | — | 1 | 7.80 |
| CHEMBL411338 | — | — | 1 | 7.73 |
| CHEMBL216640 | — | — | 1 | 7.59 |
| CHEMBL2370627 | — | — | 1 | 6.63 |
| CHEMBL2370629 | — | — | 1 | 6.62 |
| CHEMBL2370622 | — | — | 1 | 6.61 |
| CHEMBL2370611 | — | — | 1 | 6.50 |
| CHEMBL404929 | — | — | 1 | 6.41 |
| CHEMBL2370612 | — | — | 1 | 6.14 |
| CHEMBL2370626 | — | — | 1 | 6.00 |
| CHEMBL2111843 | — | — | 1 | 5.99 |
| CHEMBL2370610 | — | — | 1 | 5.87 |
| CHEMBL414713 | — | — | 1 | 5.86 |
| CHEMBL374268 | — | — | 1 | 5.76 |
| CHEMBL263509 | — | — | 1 | 5.72 |
| CHEMBL2370628 | — | — | 1 | 5.70 |
| CHEMBL2369128 | — | — | 1 | 5.66 |
| CHEMBL2370631 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112652 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL2370618 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL411338 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL216640 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL2370627 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL2370629 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL2370622 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL2370611 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL404929 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2370612 | — | IC50 | = | 717.0 | nM | 6.14 |
| CHEMBL2370626 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2111843 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2370610 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL414713 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL374268 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL263509 | — | IC50 | = | 1908.0 | nM | 5.72 |
| CHEMBL2370628 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2369128 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL2370631 | — | IC50 | = | 2340.0 | nM | 5.63 |