Assay Detail
Binding
CHEMBL750003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its receptor binding affinity at [3H]cyclo[D-pen2,p-cl-Phe4,D-Pen5](delta receptor) to opioid receptor in guinea pig brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.58 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268874 | — | — | 1 | 7.59 |
| CHEMBL262963 | — | — | 1 | 6.14 |
| CHEMBL415795 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268874 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL262963 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL415795 | — | IC50 | = | 1000.0 | nM | 6.00 |