Assay Detail
Functional
CHEMBL750026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The IC50 value was measured on OVCAR-8 cell line in ovarian tumor type.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-8 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.11 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 8.62 |
| CHEMBL44919 | — | — | 1 | 8.23 |
| CHEMBL42819 | — | — | 1 | 8.09 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL44919 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL42819 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 31.0 | nM | 7.51 |