Assay Detail
Functional
CHEMBL750052
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Agonistic potency against nicotinic acetylcholine receptor alpha3-beta4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907594) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and nicotinic receptor activity of a hydroxylated tropane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.26 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 7.72 |
| CHEMBL421553 | — | — | 1 | 5.68 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL421553 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3 | NICOTINE | EC50 | = | 4300.0 | nM | 5.37 |