Assay Detail
Binding
CHEMBL750071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radioligand [3H]- U-69,593 on Opioid receptor kappa 1 in monkey brain membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-Deoxyclocinnamox: the first high-affinity, nonpeptide mu-opioid antagonist lacking a phenolic hydroxyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.84 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386492 | CLOCINNAMOX | — | 1 | 8.14 |
| CHEMBL386272 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386492 | CLOCINNAMOX | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL386272 | — | Ki | = | 29.0 | nM | 7.54 |