Assay Detail
Binding
CHEMBL750074
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Compound was tested for Inhibition of [3H]-DPDPE (0.2 nM) binding to Opioid receptor kappa 1 from bovine striatal Membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and opioid binding properties of 2-chloroacrylamido derivatives of 7,8-dihydromorphinans
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.36 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289426 | — | — | 1 | 8.81 |
| CHEMBL41366 | — | — | 1 | 7.58 |
| CHEMBL290616 | — | — | 1 | 6.74 |
| CHEMBL288178 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289426 | — | IC50 | = | 1.53 | nM | 8.81 |
| CHEMBL41366 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL290616 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL288178 | — | IC50 | = | 501.0 | nM | 6.30 |