Assay Detail

CHEMBL750085

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Binding

Ability to displace radioligand [3H](-)-cytisine from Neuronal nicotinic receptor in rat brain membrane was determined.

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Tissue	Brain
Subcellular	Membrane
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthesis and biological evaluation of pyridine-modified analogues of 3-(2-aminoethoxy)pyridine as novel nicotinic receptor ligands.

Lin NH, Dong L, Bunnelle WH, Anderson DJ, Meyer MD.
Bioorg Med Chem Lett (2002) 12 : 3321 -3324
PubMed 12392742 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.30	10.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL430497	TEBANICLINE	2.0	1	10.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL430497	TEBANICLINE	Ki	=	0.05	nM	10.30