Assay Detail
Binding
CHEMBL750166
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Inhibition of human endothelial nitric oxide synthase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fluorinated dihydroquinolines as potent n-NOS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.86 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349071 | — | — | 1 | 5.57 |
| CHEMBL61969 | — | — | 1 | 5.48 |
| CHEMBL314943 | — | — | 1 | 5.24 |
| CHEMBL292099 | — | — | 1 | 5.21 |
| CHEMBL162416 | — | — | 1 | 5.03 |
| CHEMBL314186 | — | — | 1 | 4.85 |
| CHEMBL162455 | — | — | 1 | 4.85 |
| CHEMBL86961 | — | — | 1 | 4.70 |
| CHEMBL350281 | — | — | 1 | 4.66 |
| CHEMBL161925 | — | — | 1 | 4.42 |
| CHEMBL354230 | — | — | 1 | 4.18 |
| CHEMBL162365 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349071 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL61969 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL314943 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL292099 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL162416 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL314186 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL162455 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL86961 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL350281 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL161925 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL354230 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL162365 | — | IC50 | = | 79000.0 | nM | 4.10 |