Assay Detail
Functional
CHEMBL750188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against orphan FQ receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.15 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111347 | — | — | 1 | 7.92 |
| CHEMBL111192 | — | — | 1 | 7.92 |
| CHEMBL111230 | — | — | 1 | 7.48 |
| CHEMBL109598 | — | — | 1 | 7.33 |
| CHEMBL112974 | — | — | 1 | 7.09 |
| CHEMBL113684 | — | — | 1 | 6.99 |
| CHEMBL322515 | — | — | 1 | 6.94 |
| CHEMBL109563 | — | — | 1 | 6.87 |
| CHEMBL325536 | — | — | 1 | 6.65 |
| CHEMBL320991 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111347 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL111192 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL111230 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL109598 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL112974 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL113684 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL322515 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL109563 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL325536 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL320991 | — | Ki | = | 502.0 | nM | 6.30 |