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Assay Detail

CHEMBL750199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for in vitro inhibition of osteoclast vacuolar acid pump
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Adenosinetriphosphatase (CHEMBL2770)
Type SINGLE PROTEIN
Organism Gallus gallus

Publication

Solid phase synthesis of diamides as potential bone resorption inhibitors.
Edvinsson KM, Herslöf M, Holm P, Kann N, Keeling DJ, Mattsson JP, Nordén B, Shcherbukhin V.
Bioorg Med Chem Lett (2000) 10 : 503 -507
PubMed 10743958 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.57 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL148720 1 5.82
CHEMBL147307 1 5.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL148720 IC50 = 1500.0 nM 5.82
CHEMBL147307 IC50 = 4900.0 nM 5.31