Assay Detail
Binding
CHEMBL750247
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Inhibition of hepatitis C virus (HCV) NS3/NS4A serine protease
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.62 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349186 | — | — | 1 | 11.00 |
| CHEMBL160002 | — | — | 1 | 9.30 |
| CHEMBL406457 | — | — | 1 | 8.82 |
| CHEMBL404815 | — | — | 1 | 8.70 |
| CHEMBL162028 | — | — | 1 | 8.15 |
| CHEMBL421233 | — | — | 1 | 7.52 |
| CHEMBL417559 | — | — | 1 | 7.40 |
| CHEMBL433693 | — | — | 1 | 7.00 |
| CHEMBL216587 | — | — | 1 | 6.82 |
| CHEMBL217122 | — | — | 1 | 6.22 |
| CHEMBL350080 | — | — | 1 | 6.19 |
| CHEMBL159723 | — | — | 1 | 6.16 |
| CHEMBL216588 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349186 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL160002 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL406457 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL404815 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL162028 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL421233 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL417559 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL433693 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL216587 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL217122 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL350080 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL159723 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL216588 | — | Ki | = | 1500.0 | nM | 5.82 |