Assay Detail
Binding
CHEMBL750248
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Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.40 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173466 | — | — | 1 | 8.10 |
| CHEMBL366575 | — | — | 1 | 7.82 |
| CHEMBL366574 | — | — | 1 | 7.72 |
| CHEMBL176905 | — | — | 1 | 7.70 |
| CHEMBL424769 | — | — | 1 | 7.43 |
| CHEMBL367225 | — | — | 1 | 7.30 |
| CHEMBL174670 | — | — | 1 | 7.22 |
| CHEMBL175002 | — | — | 1 | 7.05 |
| CHEMBL369000 | — | — | 1 | 7.00 |
| CHEMBL177073 | — | — | 1 | 6.92 |
| CHEMBL367430 | — | — | 1 | 6.85 |
| CHEMBL368852 | — | — | 1 | 6.82 |
| CHEMBL176924 | — | — | 1 | 6.80 |
| CHEMBL353549 | — | — | 1 | 6.40 |
| CHEMBL369397 | — | — | 1 | 6.40 |
| CHEMBL177283 | — | — | 1 | 6.40 |
| CHEMBL174225 | — | — | 1 | 6.40 |
| CHEMBL368163 | — | — | 1 | 6.34 |
| CHEMBL367243 | — | — | 1 | 6.16 |
| CHEMBL443828 | — | — | 1 | 5.82 |
| CHEMBL368787 | — | — | 1 | 5.82 |
| CHEMBL175177 | — | — | 1 | 5.80 |
| CHEMBL172902 | — | — | 1 | 5.72 |
| CHEMBL366842 | — | — | 1 | 5.70 |
| CHEMBL176017 | — | — | 1 | 5.70 |
| CHEMBL174007 | — | — | 1 | 5.66 |
| CHEMBL176335 | — | — | 1 | 5.54 |
| CHEMBL426226 | — | — | 1 | 5.52 |
| CHEMBL353561 | — | — | 1 | 5.40 |
| CHEMBL177733 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173466 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL366575 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL366574 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL176905 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL424769 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL367225 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL174670 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL175002 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL369000 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL177073 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL367430 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL368852 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL176924 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL369397 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL353549 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL174225 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL177283 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL368163 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL367243 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL443828 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL368787 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL175177 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL172902 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL366842 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL176017 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL174007 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL176335 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL426226 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL353561 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL177733 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL366941 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL173638 | — | IC50 | = | 12000.0 | nM | 4.92 |