Assay Detail
Binding
CHEMBL750250
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Inhibitory activity against NS5B polymerase of hepatitis C virus
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 4.88 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175177 | — | — | 1 | 5.80 |
| CHEMBL368168 | — | — | 1 | 5.75 |
| CHEMBL174629 | — | — | 1 | 5.47 |
| CHEMBL362058 | — | — | 1 | 5.43 |
| CHEMBL174683 | — | — | 1 | 5.37 |
| CHEMBL434136 | — | — | 1 | 5.34 |
| CHEMBL176662 | — | — | 1 | 5.23 |
| CHEMBL174564 | — | — | 1 | 5.20 |
| CHEMBL366941 | — | — | 1 | 5.15 |
| CHEMBL361434 | — | — | 1 | 5.07 |
| CHEMBL426227 | — | — | 1 | 5.00 |
| CHEMBL178076 | — | — | 1 | 4.92 |
| CHEMBL368626 | — | — | 1 | 4.92 |
| CHEMBL174542 | — | — | 1 | 4.89 |
| CHEMBL177302 | — | — | 1 | 4.89 |
| CHEMBL174836 | — | — | 1 | 4.77 |
| CHEMBL173718 | — | — | 1 | 4.72 |
| CHEMBL353546 | — | — | 1 | 4.70 |
| CHEMBL175174 | — | — | 1 | 4.57 |
| CHEMBL175173 | — | — | 1 | 4.55 |
| CHEMBL174838 | — | — | 1 | 4.55 |
| CHEMBL174053 | — | — | 1 | 4.36 |
| CHEMBL177588 | — | — | 1 | 4.31 |
| CHEMBL177835 | — | — | 1 | 4.30 |
| CHEMBL176038 | — | — | 1 | 4.24 |
| CHEMBL177701 | — | — | 1 | 4.21 |
| CHEMBL175685 | — | — | 1 | 4.12 |
| CHEMBL369640 | — | — | 1 | - |
| CHEMBL177851 | — | — | 1 | - |
| CHEMBL174331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175177 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL368168 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL174629 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL362058 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL174683 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL434136 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL176662 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL174564 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL366941 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL361434 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL426227 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL178076 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL368626 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL174542 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL177302 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL174836 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL173718 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL353546 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL175174 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL175173 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL174838 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL174053 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL177588 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL177835 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL176038 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL177701 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL175685 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL355577 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL175762 | — | IC50 | = | 139000.0 | nM | - |
| CHEMBL178045 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL178067 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL176034 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL177456 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL177345 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL177566 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL177932 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL174392 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL368583 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL174955 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL177810 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL176593 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL367758 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL175454 | — | IC50 | = | 360000.0 | nM | - |
| CHEMBL177122 | — | IC50 | = | 186000.0 | nM | - |
| CHEMBL174331 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL177851 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL369640 | — | IC50 | = | 408000.0 | nM | - |