Assay Detail
Binding
CHEMBL750253
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Inhibitory potency against NS5B HCV polymerase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.76 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109569 | — | — | 1 | 5.65 |
| CHEMBL323046 | — | — | 1 | 4.79 |
| CHEMBL321642 | — | — | 1 | 4.62 |
| CHEMBL324883 | — | — | 1 | 4.44 |
| CHEMBL109448 | — | — | 1 | 4.29 |
| CHEMBL109823 | — | — | 1 | - |
| CHEMBL262711 | — | — | 1 | - |
| CHEMBL109969 | — | — | 1 | - |
| CHEMBL110021 | — | — | 1 | - |
| CHEMBL109516 | — | — | 1 | - |
| CHEMBL109258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109569 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL323046 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL321642 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL324883 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL109448 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL109823 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL262711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109969 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL110021 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109516 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109258 | — | IC50 | > | 100000.0 | nM | - |