Assay Detail
Binding
CHEMBL750293
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Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Application of the multipin peptide synthesis technique for peptide receptor binding studies: Substance P as A model system
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.71 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 9.43 |
| CHEMBL2370874 | — | — | 1 | 8.64 |
| CHEMBL2370873 | — | — | 1 | 7.51 |
| CHEMBL217406 | NEUROKININ A | — | 1 | 7.50 |
| CHEMBL436706 | KASSININ | — | 1 | 7.12 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL2370874 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2370873 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL217406 | NEUROKININ A | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL436706 | KASSININ | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL437797 | NEUROKININ B | IC50 | = | 870.0 | nM | 6.06 |