Assay Detail
Functional
CHEMBL750319
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Inhibition of farnesylation in NIH-3T3H-ras cell line
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 8.15 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24043 | — | — | 1 | 10.00 |
| CHEMBL22703 | — | — | 1 | 8.91 |
| CHEMBL25620 | — | — | 1 | 8.85 |
| CHEMBL22702 | — | — | 2 | 8.56 |
| CHEMBL24048 | — | — | 1 | 8.42 |
| CHEMBL23578 | — | — | 1 | 8.41 |
| CHEMBL26068 | — | — | 1 | 8.40 |
| CHEMBL24733 | — | — | 1 | 8.10 |
| CHEMBL283051 | — | — | 1 | 8.02 |
| CHEMBL282349 | — | — | 1 | 8.01 |
| CHEMBL23753 | — | — | 1 | 7.31 |
| CHEMBL277646 | — | — | 1 | 7.00 |
| CHEMBL23370 | — | — | 1 | 6.89 |
| CHEMBL24271 | — | — | 1 | 6.77 |
| CHEMBL24159 | — | — | 1 | - |
| CHEMBL26511 | — | — | 1 | - |
| CHEMBL25621 | — | — | 1 | - |
| CHEMBL24554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24043 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL22703 | — | EC50 | = | 1.24 | nM | 8.91 |
| CHEMBL25620 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL22702 | — | EC50 | = | 2.74 | nM | 8.56 |
| CHEMBL22702 | — | EC50 | = | 2.74 | nM | 8.56 |
| CHEMBL24048 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL23578 | — | EC50 | = | 3.86 | nM | 8.41 |
| CHEMBL26068 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL24733 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL283051 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL282349 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL23753 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL277646 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL23370 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL24271 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL25621 | — | EC50 | < | 1.0 | nM | - |
| CHEMBL26511 | — | EC50 | < | 0.1 | nM | - |
| CHEMBL24554 | — | EC50 | < | 1.0 | nM | - |
| CHEMBL24159 | — | EC50 | < | 1.0 | nM | - |