Assay Detail
Binding
CHEMBL750363
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Binding affinity to norepinephrine (NE) transporter in membranes of cells selectively expressing the human genes for NET
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.45 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311347 | — | — | 1 | 7.95 |
| CHEMBL66068 | — | — | 1 | 6.93 |
| CHEMBL67387 | — | — | 1 | 5.98 |
| CHEMBL294733 | — | — | 1 | 5.87 |
| CHEMBL303494 | — | — | 1 | 5.52 |
| CHEMBL303232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311347 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL66068 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL67387 | — | Ki | = | 1039.0 | nM | 5.98 |
| CHEMBL294733 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL303494 | — | Ki | = | 3024.0 | nM | 5.52 |
| CHEMBL303232 | — | Ki | > | 20000.0 | nM | - |