Assay Detail
Binding
CHEMBL750421
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Binding affinity for Opioid receptor delta 1 by the inhibition of binding of [3H]-p-DPDPE human cloned receptors.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.00 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | — | 1 | 8.89 |
| CHEMBL98800 | — | — | 1 | 8.30 |
| CHEMBL101316 | — | — | 1 | 8.12 |
| CHEMBL431276 | — | — | 1 | 8.10 |
| CHEMBL102150 | — | — | 1 | 7.99 |
| CHEMBL430675 | — | — | 1 | 7.89 |
| CHEMBL316845 | — | — | 1 | 7.75 |
| CHEMBL101231 | — | — | 1 | 7.58 |
| CHEMBL98691 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL98800 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL101316 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL431276 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL102150 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL430675 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL316845 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL101231 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL98691 | — | IC50 | = | 38.0 | nM | 7.42 |