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Assay Detail

CHEMBL750422

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding inhibition of [3H]- -naltrindole (0.15 nM) to membranes in CHO cells expressing Opioid receptor delta 1
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin.
Cottney J, Rankovic Z, Morphy JR.
Bioorg Med Chem Lett (1999) 9 : 1323 -1328
PubMed 10340622 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 7.11 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL611160 1 8.96
CHEMBL13470 SNC-80 1 8.66
CHEMBL24569 1 8.52
CHEMBL283466 1 8.40
CHEMBL1169547 1 8.39
CHEMBL611161 1 8.28
CHEMBL28337 1 8.14
CHEMBL2374437 1 8.13
CHEMBL24035 1 8.10
CHEMBL611165 1 7.66
CHEMBL283335 1 7.35
CHEMBL262634 1 7.08
CHEMBL611163 1 6.62
CHEMBL281680 1 6.60
CHEMBL24568 1 6.44
CHEMBL280801 1 6.38
CHEMBL611162 1 6.35
CHEMBL24293 1 6.30
CHEMBL27934 1 6.22
CHEMBL286161 1 5.86
CHEMBL283520 1 5.76
CHEMBL24039 1 5.72
CHEMBL24927 1 5.58
CHEMBL26826 1 5.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL611160 IC50 = 1.1 nM 8.96
CHEMBL13470 SNC-80 IC50 = 2.2 nM 8.66
CHEMBL24569 IC50 = 3.0 nM 8.52
CHEMBL283466 IC50 = 4.0 nM 8.40
CHEMBL1169547 IC50 = 4.1 nM 8.39
CHEMBL611161 IC50 = 5.3 nM 8.28
CHEMBL28337 IC50 = 7.2 nM 8.14
CHEMBL2374437 IC50 = 7.4 nM 8.13
CHEMBL24035 IC50 = 8.0 nM 8.10
CHEMBL611165 IC50 = 22.0 nM 7.66
CHEMBL283335 IC50 = 44.3 nM 7.35
CHEMBL262634 IC50 = 82.4 nM 7.08
CHEMBL611163 IC50 = 240.0 nM 6.62
CHEMBL281680 IC50 = 250.0 nM 6.60
CHEMBL24568 IC50 = 360.0 nM 6.44
CHEMBL280801 IC50 = 420.0 nM 6.38
CHEMBL611162 IC50 = 450.0 nM 6.35
CHEMBL24293 IC50 = 500.0 nM 6.30
CHEMBL27934 IC50 = 607.0 nM 6.22
CHEMBL286161 IC50 = 1394.0 nM 5.86
CHEMBL283520 IC50 = 1724.0 nM 5.76
CHEMBL24039 IC50 = 1904.0 nM 5.72
CHEMBL24927 IC50 = 2600.0 nM 5.58
CHEMBL26826 IC50 = 8097.0 nM 5.09