Assay Detail
Binding
CHEMBL750428
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Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta4 (CHEMBL1907595) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.80 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 9.80 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 7.40 |
| CHEMBL170873 | — | — | 1 | 7.39 |
| CHEMBL425135 | — | — | 1 | 6.20 |
| CHEMBL367641 | — | — | 1 | 5.02 |
| CHEMBL173610 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.157 | nM | 9.80 |
| CHEMBL3 | NICOTINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL170873 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL425135 | — | Ki | = | 637.0 | nM | 6.20 |
| CHEMBL367641 | — | Ki | = | 9460.0 | nM | 5.02 |
| CHEMBL173610 | — | Ki | = | 10500.0 | nM | 4.98 |