Assay Detail
Functional
CHEMBL750429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta4 (CHEMBL1907595) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Epibatidine structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.16 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301901 | — | — | 1 | 7.70 |
| CHEMBL56682 | — | — | 1 | 6.62 |
| CHEMBL56817 | DESCHLOROEPIBATIDINE | — | 1 | 6.01 |
| CHEMBL56358 | — | — | 1 | 5.74 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 4.72 |
| CHEMBL6623 | EPIBATIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301901 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL56682 | — | EC50 | = | 239.0 | nM | 6.62 |
| CHEMBL56817 | DESCHLOROEPIBATIDINE | EC50 | = | 982.0 | nM | 6.01 |
| CHEMBL56358 | — | EC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL6623 | EPIBATIDINE | EC50 | = | 17.0 | % | - |